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Simultaneous entry as an adaptation to virulence in a novel satellite-helper system infecting Streptomyces species

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dc.contributor.authordeCarvalho, Tagide
dc.contributor.authorMascolo, Elia
dc.contributor.authorCaruso, Steven
dc.contributor.authorLópez-Pérez, Júlia
dc.contributor.authorWeston-Hafer, Kathleen
dc.contributor.authorShaffer, Christopher
dc.contributor.authorErill, Ivan
dc.date.accessioned2023-11-27T20:08:24Z
dc.date.available2023-11-27T20:08:24Z
dc.date.issued2023-10-31
dc.description.abstractSatellites are mobile genetic elements that are dependent upon the replication machinery of their helper viruses. Bacteriophages have provided many examples of satellite nucleic acids that utilize their helper morphogenic genes for propagation. Here we describe two novel satellite-helper phage systems, Mulch and Flayer, that infect Streptomyces species. The satellites in these systems encode for encapsidation machinery but have an absence of key replication genes, thus providing the first example of bacteriophage satellite viruses. We also show that codon usage of the satellites matches the tRNA gene content of the helpers. The satellite in one of these systems, Flayer, does not appear to integrate into the host genome, which represents the first example of a virulent satellite phage. The Flayer satellite has a unique tail adaptation that allows it to attach to its helper for simultaneous co-infection. These findings demonstrate an ever-increasing array of satellite strategies for genetic dependence on their helpers in the evolutionary arms race between satellite and helper phages.
dc.description.sponsorshipElia Mascolo was funded through a Research Assistant Fellowship from the Merck Data Science for Observational Research Program. This work was supported by the UMBC Department of Biological Sciences, the UMBC College of Natural and Mathematical Sciences, the Department of Biology at Washington University in St. Louis and the Howard Hughes Medical Institute SEA-PHAGES program.
dc.description.urihttps://www.nature.com/articles/s41396-023-01548-0
dc.format.extent8 pages
dc.genrejournal articles
dc.identifier.citationdeCarvalho, Tagide, Elia Mascolo, Steven M. Caruso, Júlia López-Pérez, Kathleen Weston-Hafer, Christopher Shaffer, and Ivan Erill. “Simultaneous Entry as an Adaptation to Virulence in a Novel Satellite-Helper System Infecting Streptomyces Species.” The ISME Journal, October 31, 2023, 1–8. https://doi.org/10.1038/s41396-023-01548-0.
dc.identifier.urihttps://doi.org/10.1038/s41396-023-01548-0
dc.identifier.urihttp://hdl.handle.net/11603/30857
dc.language.isoen_US
dc.publisherNature
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Office of the Dean of the College of Natural and Mathematical Sciences
dc.relation.ispartofUMBC Keith R. Porter Imaging Facility
dc.relation.ispartofUMBC Computer Science and Electrical Engineering Department
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International (CC BY 4.0 DEED)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleSimultaneous entry as an adaptation to virulence in a novel satellite-helper system infecting Streptomyces species
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0003-0774-3096
dcterms.creatorhttps://orcid.org/0000-0003-2977-7844
dcterms.creatorhttps://orcid.org/0000-0001-9166-9137
dcterms.creatorhttps://orcid.org/0000-0002-7280-7191

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