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Evolution as a Guide to Designing xeno Amino Acid Alphabets

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dc.contributor.authorMayer-Bacon, Christopher
dc.contributor.authorAgboha, Neyiasuo
dc.contributor.authorMuscalli, Mickey
dc.contributor.authorFreeland, Stephen
dc.date.accessioned2021-03-26T18:38:13Z
dc.date.available2021-03-26T18:38:13Z
dc.date.issued2021-03-10
dc.description.abstractHere, we summarize a line of remarkably simple, theoretical research to better understand the chemical logic by which life’s standard alphabet of 20 genetically encoded amino acids evolved. The connection to the theme of this Special Issue, “Protein Structure Analysis and Prediction with Statistical Scoring Functions”, emerges from the ways in which current bioinformatics currently lacks empirical science when it comes to xenoproteins composed largely or entirely of amino acids from beyond the standard genetic code. Our intent is to present new perspectives on existing data from two different frontiers in order to suggest fresh ways in which their findings complement one another. These frontiers are origins/astrobiology research into the emergence of the standard amino acid alphabet, and empirical xenoprotein synthesisen_US
dc.description.sponsorshipThe authors would like to acknowledge the help of Alexander Chin (UMBC, Biology) whose activity in a recent graduate seminar class stimulated many of the ideas presented hereen_US
dc.description.urihttps://www.mdpi.com/1422-0067/22/6/2787en_US
dc.format.extent13 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2uscl-ggij
dc.identifier.citationMayer-Bacon, Christopher; Agboha, Neyiasuo; Muscalli, Mickey; Freeland, Stephen. 2021. "Evolution as a Guide to Designing xeno Amino Acid Alphabets" Int. J. Mol. Sci. 22, no. 6: 2787. https://doi.org/10.3390/ijms22062787en_US
dc.identifier.urihttps://doi.org/10.3390/ijms22062787
dc.identifier.urihttp://hdl.handle.net/11603/21233
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Individualized Study Program (INDS)
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleEvolution as a Guide to Designing xeno Amino Acid Alphabetsen_US
dc.typeTexten_US

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