Iorga, AndreaVelezis, Marti JMarinac-Dabic, DanicaLario, Robert FHuff, Stanley MGore, BethMermel, Leonard ABailey, L CharlesSkapik, JuliaWillis, DebiLee, Robert EHurst, Frank PGressler, Laura EReed, Terrie LTowbin, RichardBaskin, Kevin M2023-12-012023-12-012023-11-24Iorga, Andrea, Marti J. Velezis, Danica Marinac-Dabic, Robert F. Lario, Stanley M. Huff, Beth Gore, Leonard A. Mermel, et al. “Venous Access: National Guideline and Registry Development (VANGUARD): Advancing Patient-Centered Venous Access Care Through the Development of a National Coordinated Registry Network.” Journal of Medical Internet Research 25, no. 1 (November 24, 2023): e43658. https://doi.org/10.2196/43658.https://doi.org/10.2196/43658http://hdl.handle.net/11603/31003There are over 8 million central venous access devices inserted each year, many in patients with chronic conditions who rely on central access for life-preserving therapies. Central venous access device–related complications can be life-threatening and add tens of billions of dollars to health care costs, while their incidence is most likely grossly mis- or underreported by medical institutions. In this communication, we review the challenges that impair retention, exchange, and analysis of data necessary for a meaningful understanding of critical events and outcomes in this clinical domain. The difficulty is not only with data extraction and harmonization from electronic health records, national surveillance systems, or other health information repositories where data might be stored. The problem is that reliable and appropriate data are not recorded, or falsely recorded, at least in part because policy, payment, penalties, proprietary concerns, and workflow burdens discourage completeness and accuracy. We provide a roadmap for the development of health care information systems and infrastructure that address these challenges, framed within the context of research studies that build a framework of standardized terminology, decision support, data capture, and information exchange necessary for the task. This roadmap is embedded in a broader Coordinated Registry Network Learning Community, and facilitated by the Medical Device Epidemiology Network, a Public-Private Partnership sponsored by the US Food and Drug Administration, with the scope of advancing methods, national and international infrastructure, and partnerships needed for the evaluation of medical devices throughout their total life cycle.14 pagesen-USThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.Public Domain Mark 1.0Text